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CTLA-4 遗传多态性与哮喘易感性关系的 meta 分析

2018/09/10

   摘要
   背景:许多研究报告显示细胞毒性T淋巴细胞相关抗原4 (CTLA4) 基因多态性与哮喘易感性有关联, 但在不同人群中结果却不一致。我们对19项病例对照研究进行meta 分析以获得CTLA-4多态性与哮喘之间的关系的合理准确的评估。
   方法:我们搜索了 Pubmed、EMBASE、中国知网和万方数据库, 并从19项独立、合格的研究中提取数据。OR值、95% 置信区间 (CIs) 和线性回归模型分别用于评估关联强度和出版物偏倚。
   结果:共有19项病例对照研究, 涉及4831项病例及4534项对照。综合结果显示, +49A/G多态性与哮喘之间有显著的关联(GG + GA 与AA的OR值 = 0.82, 95% CI = 0.70-0.97, P =0 .02)。种族或年龄分层表明, CTLA-4中的 +49 GA + GG 基因型与哮喘在亚洲人(OR = 0.80, 95% CI = 0.68-0.95, P =0 .01)和儿童(OR = 0.75, 95% CI = 0.62-0.90, P =0 .002)之间有显著关联,但在白种人(OR = 0.94, 95% CI = 0.80-1.10, P =0 .44)和成人(OR = 0.85, 95% CI = 0.68-1.06, P =0 .15)之间没有显著关联。此外, 在随机效应模型下CTLA-4多态性与特应性哮喘有显著的相关性(OR = 0.81, 95% CI = 0.67-0.98, P = 0.03)。此外, -318 C/T多态性与哮喘风险之间没有显著的关联。
   结论:我们的 meta 分析结果表明, CTLA-4 的+49A/G多态性是哮喘易感性的重要危险因素, 在亚洲人、儿童和特应病患者中表现得更为明显。

 
(中日友好医院呼吸与危重症医学科 禹汶伯 摘译 林江涛 审校)
(Medicine (Baltimore). 2018 Jul;97(28).)

 
 
 
A meta-analysis of the association between CTLA-4 genetic polymorphism and susceptibility of asthma.
 
Zheng Y, Wang H1, Luo L, Liao L, You L, Wang J, Li Q.

Abstract
BACKGROUND:Numerous studies have reported an association between cytotoxic T-lymphocyte associated antigen 4 gene (CTLA4) polymorphism and susceptibility to asthma, in different populations, but the results have been inconsistent. We performed a meta-analysis of 19 published case-control studies to obtain a reasonably accurate estimation of the relationship between CTLA4 polymorphism and asthma.
METHODS:We searched the Pubmed, EMBASE, Chinese National Knowledge Infrastructure, and Wanfang databases and extracted data from 19 independent, eligible studies. Odds ratios (ORs) with 95% confidence intervals (CIs) and Egger test were separately used to assess the strength of associations and publication bias.
RESULTS:A total of 19 case-control studies involving 4831 cases and 4534 controls were identified. The combined results revealed that there was significant association between the +49A/G polymorphism and asthma (for GG + GA vs. AA: OR = 0.82, 95% CI = 0.70-0.97, P = .02). Stratification by race or age indicated a significant association between the CTLA-4 +49 GA+GG genotype and asthma in Asians (OR = 0.80, 95% CI = 0.68-0.95, P = .01) and children (OR = 0.75, 95% CI = 0.62-0.90, P = .002), but there was no association in whites (OR = 0.94, 95% CI = 0.80-1.10, P = .44) and adults (OR = 0.85, 95% CI = 0.68-1.06, P = .15). Additionally, there was a significant association with atopic asthma under the random-effects model (OR = 0.81, 95% CI = 0.67-0.98, P = .03). In addition, there was no significant association between the -318 C/T polymorphism and asthma risk.
CONCLUSIONS:Our meta-analysis results suggested that the +49A/G polymorphism in CTLA-4 was an important risk factor for asthma susceptibility, especially in Asian individuals, children, and atopic patients.




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